Cellular Reprogramming
Yamanaka factors and partial reprogramming to reverse cellular aging
The encyclopedia of longevity science
LongeviTech — The Rejuvenation Database
Browse every company, technology, and clinical trial working to extend human healthspan. Open-source knowledge for the longevity community.
Explore Technologies
Browse the latest breakthroughs in longevity science, from cellular reprogramming to targeted therapies.
Senolytics
Targeted elimination of senescent cells to restore tissue function
Gene Therapy
CRISPR and viral vector approaches to longevity gene modification
NAD+ Boosters
NMN, NR and precursors to restore cellular energy metabolism
Diagnostics
Epigenetic clocks, biomarkers, and biological age testing
Supplements
Evidence-based compounds for healthspan optimization
Stem Cells / iPSC
iPSC-derived cell therapies for tissue regeneration and replacement
Mitochondria
Restoring cellular energy production and metabolic function
Autophagy
Enhancing cellular cleanup of damaged proteins and organelles
Longevity Companies
Comprehensive database of 184 curated companies plus live clinical trial data across longevity therapeutics worldwide. The interactive app adds search filters, modality filters, stage filters, and live company-search results when JavaScript is available.
Altos Labs
Cellular Reprogramming · Phase 1 · San Francisco, USA · Founded 2021
Began early human safety testing in August 2025. Published landmark 2024 paper showing targeted OSK reprogramming extended mouse lifespan. Valued at $6.33B.
Calico (Alphabet)
Aging Research · Research · South San Francisco, USA · Founded 2013
Alphabet-backed research company focused on understanding the biology of lifespan and developing interventions for age-related diseases.
Unity Biotechnology
Senolytics · Research · South San Francisco, USA · Founded 2011
Former senolytic pioneer that shuttered in September 2025 after strategic pivots failed. Was developing UBX1325 for age-related eye diseases before closure.
Retro Biosciences
Cellular Reprogramming · Phase 1 · Redwood City, USA · Founded 2021
Sam Altman-backed company raising $1B at $5B valuation. Started first human trials for RTR242 (autophagy booster) targeting Alzheimer's in 2025.
Loyal
Canine Longevity · Phase 3 · San Francisco, USA · Founded 2019
First company to receive FDA RXE and TAS acceptance for lifespan extension drug LOY-002. Completed pivotal STAY study enrollment (1,300 dogs) in July 2025.
Juvenescence
Multiple Modalities · Phase 1 · Isle of Man, UK · Founded 2017
Building a diverse portfolio of longevity therapeutics including senolytics, NAD+ precursors, and autophagy enhancers.
Life Biosciences
Aging Pathways · Preclinical · Boston, USA · Founded 2017
Platform company with subsidiaries targeting different hallmarks of aging including mitochondrial dysfunction and cellular senescence.
BioAge Labs
AI Drug Discovery · Phase 1 · Richmond, USA · Founded 2015
Discontinued azelaprag in Dec 2024 due to safety concerns. Now advancing BGE-102 (NLRP3 inhibitor) with Phase 1 data expected late 2025.
Oisín Biotechnologies
Gene Therapy Senolytics · Preclinical · Seattle, USA · Founded 2016
Developing lipid nanoparticle-based gene therapy to selectively eliminate senescent cells using suicide gene approach.
Turn Biotechnologies
mRNA Reprogramming · Preclinical · Mountain View, USA · Founded 2018
Planning clinical trials for skin rejuvenation in 2026. Acquired ARMMs vesicular technology and signed LOI with Klotho Neurosciences in 2025.
Cambrian Biopharma
Portfolio Approach · Phase 2 · New York, USA · Founded 2018
Operating 7 pipeline companies with 4 assets in clinical trials as of Nov 2025. Lead candidate ATX-304 (AMPK activator) in Phase 2 for cardiometabolic diseases.
Rejuvenate Bio
Gene Therapy · Preclinical · San Diego, USA · Founded 2017
Developing combination gene therapies targeting multiple longevity genes simultaneously. Demonstrated lifespan extension in mice.
Insilico Medicine
AI Drug Discovery · Phase 2 · Hong Kong · Founded 2014
Completed Hong Kong IPO in Dec 2025 raising $293M. Lead AI-designed drug Rentosertib showed positive Phase 2a results for idiopathic pulmonary fibrosis.
Elevian
Blood Factors · Preclinical · Boston, USA · Founded 2017
Developing medicines based on GDF11 and other circulating factors that decline with age and can promote tissue regeneration.
Shift Bioscience
Reprogramming · Research · Cambridge, UK · Founded 2020
Raised $16M seed funding in 2024/2025 for cellular reprogramming using machine learning to identify optimal transcription factor combinations.
NewLimit
Epigenetic Reprogramming · Preclinical · San Francisco, USA · Founded 2021
Raised $130M Series B (May 2025) + $45M extension (Oct 2025) at $1.62B valuation. Nominated first preclinical candidate for liver regeneration.
Rubedo Life Sciences
Senolytics · Phase 1 · Sunnyvale, USA · Founded 2020
Dosed first patient in Phase 1 trial for RLS-1496 (topical GPX4 modulator) for plaque psoriasis and skin aging in late 2024.
LyGenesis
Organ Regeneration · Phase 2 · Pittsburgh, USA · Founded 2017
Revolutionary approach using lymph nodes as bioreactors to grow functional ectopic organs for patients with end-stage organ failure.
Gero
AI Drug Discovery · Research · Singapore · Founded 2015
AI-driven platform identifying interventions that target the fundamental causes of aging using longitudinal health data analysis.
BlueRock Therapeutics
Cell Therapy · Phase 1 · Cambridge, USA · Founded 2016
Bayer subsidiary developing iPSC-derived cell therapies for Parkinson's disease, heart failure, and other degenerative conditions.
Clock.bio
Reprogramming Atlas · Research · Copenhagen, Denmark · Founded 2022
Building the Atlas of Rejuvenation using iPSCs and CRISPR screens to systematically map cellular rejuvenation factors.
Genflow Biosciences
SIRT6 Gene Therapy · Preclinical · Brussels, Belgium · Founded 2021
Publicly traded company developing SIRT6 gene therapies for metabolic dysfunction-associated steatohepatitis and Werner syndrome.
Cellvie
Mitochondrial Therapy · Preclinical · Boston, USA · Founded 2019
Developing mitochondrial transplantation therapies to restore cellular energy production and treat age-related diseases.
Dorian Therapeutics
Senescence · Research · New York, USA · Founded 2019
Targeting cellular senescence with small molecules that prevent cells from becoming senescent (senoblockers) rather than killing them.
Alkahest
Blood Factors · Phase 2 · San Carlos, USA · Founded 2014
Grifols subsidiary developing plasma-derived therapies based on age-related changes in blood composition for neurodegeneration.
Fauna Bio
Hibernation Biology · Research · Emeryville, USA · Founded 2018
Studying hibernating animals to discover protective mechanisms against ischemia, muscle wasting, and metabolic stress.
Repair Biotechnologies
Cholesterol Degradation · Preclinical · Rochester, USA · Founded 2018
Engineering immune cells to degrade cholesterol deposits in arteries, addressing atherosclerosis at its root cause.
Hevolution Foundation
Longevity Funding · Research · Riyadh, Saudi Arabia · Founded 2021
World's largest philanthropic funder of geroscience, committing over $400M by mid-2024. Invested $20M in Aeovian Pharmaceuticals for mTORC1 inhibitors.
Cyclarity Therapeutics
Atherosclerosis · Preclinical · San Francisco, USA · Founded 2019
Developing cyclodextrin-based therapeutics to remove oxidized cholesterol (7-ketocholesterol) from arterial plaques.
Underdog Pharmaceuticals
Cardiovascular Aging · Preclinical · San Francisco, USA · Founded 2020
Developing small molecules to prevent toxic oxysterol accumulation and maintain cellular membrane health with aging.
Intervene Immune
Thymus Regeneration · Phase 2 · Los Angeles, USA · Founded 2016
TRIIM clinical trials demonstrated biological age reversal using growth hormone, DHEA, and metformin to regenerate the thymus and restore immune function.
Deciduous Therapeutics
Seno-Immunotherapy · Preclinical · San Francisco, USA · Founded 2020
Developing medicines that activate the endogenous immune mechanism responsible for eliminating senescent cells naturally.
Stealth BioTherapeutics
Mitochondrial Medicine · Approved · Newton, USA · Founded 2006
Elamipretide received FDA accelerated approval for mitochondrial dysfunction. Targeting dry AMD and other age-related mitochondrial diseases.
Centaura
Aging Gene Therapy · Research · Boston, USA · Founded 2021
Developing gene therapies targeting core aging mechanisms to extend healthspan using novel delivery systems.
Renewal Bio
Synthetic Embryos · Research · Tel Aviv, Israel · Founded 2021
Creating synthetic embryo models to produce young cells and tissues for regenerative medicine without traditional embryos.
Epiterna
Pet & Human Longevity · Research · Switzerland · Founded 2021
High-throughput screening platform to discover small molecules that extend healthy lifespan in pets first, then humans.
Integrated Biosciences
AI Drug Discovery · Preclinical · San Francisco, USA · Founded 2020
Using machine learning to discover molecules targeting cellular stress responses and aging pathways.
Longevica
Geroprotectors · Research · London, UK · Founded 2019
Developing small molecule geroprotectors based on validated longevity pathways and computational drug design.
SENS Research Foundation
Damage Repair · Research · Mountain View, USA · Founded 2009
Non-profit pioneering the damage-repair approach to aging, funding research on the seven types of cellular damage.
Aeovian Pharmaceuticals
mTOR Inhibitors · Phase 1 · San Francisco, USA · Founded 2016
Received $20M investment from Hevolution Foundation. Developing next-gen mTORC1 inhibitors with improved selectivity for age-related diseases.
Tornado Therapeutics
Cancer & Aging · Preclinical · Cambridge, USA · Founded 2022
Leveraging DNA damage response biology to develop therapies for cancer and age-related conditions.
Arda Therapeutics
Tissue Regeneration · Research · San Francisco, USA · Founded 2022
Using single-cell genomics to understand regeneration and develop therapies for tissue repair and aging.
CohBar
Mitochondrial Peptides · Phase 1 · San Mateo, USA · Founded 2007
Developing mitochondria-based therapeutics (MBTs) derived from novel peptides encoded in mitochondrial genome.
Elysium Health
NAD+ Consumer · Commercial · New York, USA · Founded 2014
Consumer health company selling Basis (NR + pterostilbene) and developing NAD+ precursor supplements with clinical evidence.
Tally Health
Biological Age Testing · Commercial · New York, USA · Founded 2022
Consumer platform offering epigenetic age testing and personalized recommendations founded by David Sinclair.
Chronomics
Epigenetic Testing · Commercial · London, UK · Founded 2017
At-home epigenetic testing to measure biological age and track response to lifestyle interventions.
TruDiagnostic
Epigenetic Clocks · Commercial · Lexington, USA · Founded 2020
Clinical-grade epigenetic testing with TruAge biological age test and immune age analysis for physicians and consumers.
Deep Longevity
AI Aging Clocks · Commercial · Hong Kong · Founded 2020
Developing AI-powered aging clocks and psychological wellbeing assessment tools acquired by Endurance Longevity.
Humanity Inc
Rate of Aging · Commercial · London, UK · Founded 2019
Mobile app measuring rate of biological aging using wearable data and providing personalized interventions.
Gordian Biotechnology
In Vivo Screening · Research · San Francisco, USA · Founded 2020
Platform for testing thousands of gene therapies simultaneously in aged mice to discover longevity interventions.
Ora Biomedical
C. elegans Screening · Research · Seattle, USA · Founded 2021
Received NIH SBIR grant in late 2024 for EleGantry platform. Partnering with U.S. Air Force for space radiation therapeutics. Founded by Matt Kaeberlein.
Marble Therapeutics
Blood Factors · Preclinical · Boston, USA · Founded 2021
Developing therapeutics based on systemic blood factors that regulate aging and tissue regeneration.
Leucadia Therapeutics
Alzheimer's Prevention · Preclinical · San Diego, USA · Founded 2015
Novel approach to Alzheimer's treating impaired cerebrospinal fluid drainage as root cause of amyloid accumulation.
Revel Pharmaceuticals
Crosslink Breaking · Research · San Francisco, USA · Founded 2019
Developing enzyme therapies to break glucosepane crosslinks that accumulate in aging tissues causing stiffness.
Ichor Therapeutics
Macular Degeneration · Preclinical · Syracuse, USA · Founded 2013
Developing enzyme replacement therapy to clear lipofuscin (A2E) accumulation in retinal cells causing AMD.
Senolytic Therapeutics
Senolytics · Preclinical · Barcelona, Spain · Founded 2019
Spanish biotech developing novel senolytic compounds for age-related diseases and healthspan extension.
Cleara Biotech
Senolytics · Preclinical · Utrecht, Netherlands · Founded 2017
Developing FOXO4-DRI peptide-based senolytics that disrupt senescent cell survival mechanisms.
Senescence Life Sciences
Senolytics · Research · Cambridge, UK · Founded 2020
Developing small molecule senolytics targeting BCL-2 family proteins for selective senescent cell elimination.
Antidote Bio
Gene Therapy · Preclinical · San Francisco, USA · Founded 2020
Developing gene therapies for age-related diseases including sarcopenia and neurodegeneration.
MaxScientific
NAD+ Therapeutics · Preclinical · Boston, USA · Founded 2019
Developing NAD+ precursors and related metabolites for therapeutic applications in age-related diseases.
Yuvan Research
Plasma Dilution · Phase 1 · California, USA · Founded 2020
Developing therapeutic plasma exchange (TPE) protocols based on research showing benefits of young blood factors.
Ponce de Leon Health
Amoebocyte Lysate · Research · Florida, USA · Founded 2018
Developing therapeutics from horseshoe crab-derived factors with immune-boosting and anti-aging properties.
Apollo Health Ventures
Longevity VC · Research · Boston, USA · Founded 2018
Venture capital firm building and investing in longevity biotechs with hands-on company creation approach.
Longevity Vision Fund
Longevity VC · Research · New York, USA · Founded 2018
Venture capital fund focused exclusively on longevity sector investments across therapeutics and diagnostics.
Relation Therapeutics
AI Cell Biology · Research · London, UK · Founded 2021
Using machine learning and functional genomics to understand cellular aging and develop regenerative medicines for bone diseases.
Mitra Bio
Partial Reprogramming · Research · Cambridge, UK · Founded 2022
Developing partial reprogramming therapeutics using proprietary systems to rejuvenate cells without full dedifferentiation.
Alchemab Therapeutics
Protective Antibodies · Preclinical · London, UK · Founded 2019
Mining antibody repertoires from resilient individuals to discover protective antibodies against age-related diseases.
Aelix Therapeutics
HIV Cure · Phase 2 · Barcelona, Spain · Founded 2015
Developing therapeutic vaccines to achieve functional cure for HIV, addressing chronic infection and immune aging.
Cellectis
Gene Editing · Phase 1 · Paris, France · Founded 2000
Pioneer in TALEN gene editing technology developing allogeneic CAR-T therapies and gene-editing tools for aging research.
Oxstem
Endogenous Repair · Preclinical · Oxford, UK · Founded 2013
Small molecules that activate the body's own stem cells to regenerate damaged tissues in heart, brain, and eyes.
Celltrion
Biosimilars & Biologics · Commercial · Incheon, South Korea · Founded 2002
Major Korean biopharma developing biosimilars and novel biologics including therapies for age-related conditions.
Evotec
Drug Discovery Platform · Commercial · Hamburg, Germany · Founded 1993
German drug discovery platform company with partnerships in aging and neurodegeneration research.
Morphosys
Antibody Therapeutics · Phase 3 · Munich, Germany · Founded 1992
German biotech specializing in antibody discovery with programs targeting age-related diseases and cancer.
Lonza
CDMO Services · Commercial · Basel, Switzerland · Founded 1897
Swiss manufacturing partner enabling longevity biotech development with cell & gene therapy production capabilities.
Bachem
Peptide Manufacturing · Commercial · Bubendorf, Switzerland · Founded 1971
Swiss company manufacturing peptides and oligonucleotides critical for longevity therapeutics development.
Healios K.K.
iPSC Regenerative · Phase 2 · Tokyo, Japan · Founded 2011
Japanese leader in iPSC-derived regenerative medicine with therapies for stroke, ARDS, and organ regeneration.
Heartseed
Cardiac Regeneration · Phase 1 · Tokyo, Japan · Founded 2015
Developing iPSC-derived cardiomyocyte spheroids to regenerate damaged heart tissue after heart failure.
Megakaryon
Platelet Production · Phase 1 · Kyoto, Japan · Founded 2011
Manufacturing iPSC-derived platelets at scale for transfusion medicine and regenerative applications.
I Peace
iPSC Platform · Commercial · Tokyo, Japan · Founded 2020
Japanese iPSC services company providing cell manufacturing and research tools for regenerative medicine.
Ncardia
iPSC Drug Discovery · Commercial · Leiden, Netherlands · Founded 2015
European-Asian company providing iPSC-derived cells for drug discovery and safety testing in cardiac and neuro aging.
Pluristem Therapeutics
Placenta Cells · Phase 3 · Haifa, Israel · Founded 2003
Israeli company developing placenta-derived cell therapies for muscle regeneration and critical limb ischemia.
Kadimastem
Cell Therapy · Phase 2 · Ness Ziona, Israel · Founded 2009
Israeli biotech developing stem cell-derived therapies for ALS and diabetes using astrocyte and islet cells.
Gamida Cell
Cell Expansion · Approved · Jerusalem, Israel · Founded 1998
Israeli company with FDA-approved cell therapy (Omisirge) and platform for expanding stem cells for transplant.
Mesoblast
Allogeneic Cells · Phase 3 · Melbourne, Australia · Founded 2004
Australian leader in allogeneic cellular medicines for inflammatory and cardiovascular conditions.
Cynata Therapeutics
Cymerus MSCs · Phase 2 · Melbourne, Australia · Founded 2011
Australian company with proprietary iPSC-derived MSC platform (Cymerus) for scalable regenerative therapies.
Genexine
Gene Therapy · Phase 2 · Seoul, South Korea · Founded 1999
Korean biotech developing DNA vaccines and gene therapies including programs targeting aging-related conditions.
Sirnaomics
RNAi Therapeutics · Phase 2 · Suzhou, China · Founded 2007
China-US biotech developing RNAi therapeutics for fibrosis and scarring with novel delivery platforms.
Gracell Biotechnologies
CAR-T Therapy · Phase 2 · Shanghai, China · Founded 2017
Chinese biotech developing next-generation CAR-T cell therapies with faster manufacturing for blood cancers.
Legend Biotech
CAR-T Therapy · Approved · Nanjing, China · Founded 2014
Chinese biotech with FDA-approved BCMA CAR-T (Carvykti) and pipeline addressing age-related blood cancers.
Sino Biological
Research Reagents · Commercial · Beijing, China · Founded 2007
Chinese company providing recombinant proteins, antibodies, and reagents essential for longevity research worldwide.
Livzon Pharmaceutical
Peptide Drugs · Commercial · Zhuhai, China · Founded 1985
Chinese pharma with marketed peptide drugs and pipeline including therapies for metabolic and age-related diseases.
BeiGene
Oncology · Commercial · Beijing, China · Founded 2010
Major Chinese biotech with global oncology pipeline addressing age-related cancers with novel targeted therapies.
Juvena Therapeutics
Muscle Regeneration · Preclinical · San Francisco, USA · Founded 2016
Developing stem cell-secreted protein therapeutics to regenerate aged muscle and treat sarcopenia.
Epirium Bio
Muscle Aging · Phase 2 · San Diego, USA · Founded 2020
Developing therapies for muscle diseases including sarcopenia and Duchenne muscular dystrophy.
Myoforte Therapeutics
Sarcopenia · Preclinical · Boston, USA · Founded 2019
Targeting the myostatin pathway to develop treatments for age-related muscle loss and frailty.
Tectonic Therapeutic
GPCR Targeting · Preclinical · Boston, USA · Founded 2019
Using cryo-EM to target GPCRs for cardiometabolic and age-related diseases with novel small molecules.
Cellino Biotech
iPSC Manufacturing · Research · Cambridge, USA · Founded 2019
Developing AI-powered laser technology to manufacture iPSC-derived cells at unprecedented scale and quality.
Tract Therapeutics
Age-Related Fibrosis · Preclinical · Boston, USA · Founded 2020
Developing therapies targeting fibrosis and scarring that accumulates with aging in multiple organs.
Biosplice Therapeutics
Wnt Pathway · Phase 3 · San Diego, USA · Founded 2017
Developing Wnt pathway modulators for osteoarthritis and other degenerative diseases of aging.
Samumed
Tissue Regeneration · Phase 3 · San Diego, USA · Founded 2008
Developing small molecule therapeutics that target regenerative pathways for hair loss, arthritis, and wound healing.
Notch Therapeutics
iPSC T-Cell Therapies · Preclinical · Vancouver, Canada · Founded 2018
Developing iPSC-derived T-cell therapies using proprietary Engineered Thymic Niche technology for scalable cancer immunotherapy.
Aspect Biosystems
3D Bioprinting · Preclinical · Vancouver, Canada · Founded 2013
Pioneering bioprinted tissue therapeutics using proprietary 3D bioprinting platform for tissue engineering and regenerative medicine.
CCRM
Cell & Gene Therapy · Commercial · Toronto, Canada · Founded 2011
Global network supporting the development and commercialization of cell and gene therapies, regenerative medicine, and advanced biomanufacturing.
Deep Genomics
AI Genetic Medicine · Phase 1 · Toronto, Canada · Founded 2014
AI-powered platform discovering therapies for genetic diseases by predicting the effects of genetic variations on cellular biology.
Turnstone Biologics
Oncolytic Viruses · Phase 1 · Ottawa, Canada · Founded 2015
Developing oncolytic virus immunotherapies that selectively replicate in tumor cells and stimulate anti-cancer immune responses.
Repare Therapeutics
DNA Repair · Phase 2 · Montreal, Canada · Founded 2016
Precision oncology company developing novel therapeutics targeting DNA damage repair processes in cancer and aging.
Evox Therapeutics
Exosome Therapeutics · Preclinical · Oxford, UK / Stockholm, Sweden · Founded 2016
Engineering exosomes as a new class of drug delivery vehicles for protein and RNA therapeutics across the blood-brain barrier.
Oncopeptides
Peptide Oncology · Phase 3 · Stockholm, Sweden · Founded 2000
Developing peptide-drug conjugates for difficult-to-treat hematological cancers including relapsed/refractory multiple myeloma.
Targovax
Oncolytic Viruses · Phase 2 · Oslo, Norway · Founded 2010
Norwegian biotech developing oncolytic viruses and cancer vaccines for solid tumors with high unmet medical need.
Herantis Pharma
Regenerative Neurology · Phase 2 · Helsinki, Finland · Founded 2008
Developing CDNF-based therapies for Parkinson's disease and other neurodegenerative conditions with regenerative potential.
Ultimovacs
Cancer Vaccines · Phase 2 · Oslo, Norway · Founded 2011
Developing universal cancer vaccine UV1 targeting telomerase to treat multiple solid tumor types in combination with checkpoint inhibitors.
Affimed
NK Cell Engagers · Phase 2 · Heidelberg, Germany · Founded 2000
Developing innate cell engager (ICE) therapeutics that redirect natural killer cells to eliminate cancer cells.
BioNTech
mRNA Platform · Phase 3 · Mainz, Germany · Founded 2008
Pioneer of mRNA therapeutics with platform spanning cancer immunotherapies, infectious diseases, and regenerative medicine.
Rejuveron Life Sciences
Longevity Therapeutics · Research · Zurich, Switzerland · Founded 2019
Swiss longevity company developing therapeutics targeting the hallmarks of aging including senescence and inflammation.
MaxCyte
Cell Engineering · Commercial · Munich, Germany · Founded 1998
Providing cell engineering platform enabling development of next-generation cell therapies for aging and cancer.
Hookipa Pharma
Arenavirus Immunotherapy · Phase 2 · Vienna, Austria · Founded 2011
Developing arenavirus-based immunotherapies that generate potent and durable anti-tumor immune responses.
Polyphor
Peptide Therapeutics · Phase 3 · Basel, Switzerland · Founded 1996
Swiss company developing macrocycle peptide therapeutics for oncology and antimicrobial resistance.
Genfit
Liver Diseases · Phase 3 · Lille, France · Founded 1999
Developing therapeutic and diagnostic solutions for metabolic and liver diseases including NASH and age-related conditions.
Nanobiotix
Nanoparticle Therapeutics · Phase 3 · Paris, France · Founded 2003
Developing radioenhancer nanoparticles to improve radiotherapy outcomes for solid tumors with lead product NBTXR3.
Biophytis
Age-Related Diseases · Phase 2 · Paris, France · Founded 2006
Developing drug candidates for age-related muscle and eye diseases including sarcopenia and Duchenne muscular dystrophy.
Abivax
Immune Modulation · Phase 3 · Paris, France · Founded 2013
Developing obefazimod for inflammatory diseases by modulating RNA processing and immune cell function.
Takeda Regenerative
Cell Therapies · Phase 1 · Tokyo, Japan · Founded 2018
Takeda's regenerative medicine division developing iPSC-derived therapies for neurological and immune disorders.
Sumitomo Pharma
iPSC Retinal Cells · Phase 2 · Osaka, Japan · Founded 2005
Developing iPSC-derived retinal pigment epithelium cells for age-related macular degeneration and retinal diseases.
Astellas Regenerative
Cell & Gene Therapy · Phase 1 · Tokyo, Japan · Founded 2016
Astellas' regenerative medicine focused subsidiary developing iPSC and gene therapies for degenerative conditions.
PuREC
Pluripotent Stem Cells · Research · Kyoto, Japan · Founded 2014
Kyoto-based biotech developing clinical-grade iPSC manufacturing and differentiation for regenerative therapies.
ReproCELL
iPSC Services · Commercial · Yokohama, Japan · Founded 2003
Providing iPSC-derived cells and services for drug discovery and regenerative medicine research globally.
Acepodia
NK Cell Therapy · Phase 1 · Tokyo, Japan · Founded 2016
Japanese biotech developing natural killer cell therapies for cancer using proprietary antibody-cell conjugation technology.
Hanmi Pharmaceutical
Biologics Platform · Phase 3 · Seoul, South Korea · Founded 1973
Major Korean pharma developing biologics for metabolic and age-related diseases using proprietary LAPSCOVERY platform.
Samsung Biologics
Biomanufacturing · Commercial · Incheon, South Korea · Founded 2011
World's largest biopharmaceutical contract manufacturer enabling production of cell and gene therapies globally.
Medipost
Stem Cell Therapeutics · Approved · Seoul, South Korea · Founded 2000
Pioneer in umbilical cord blood-derived stem cell therapies with approved product CARTISTEM for cartilage regeneration.
SCM Lifescience
Cell Therapy · Phase 2 · Seoul, South Korea · Founded 2009
Developing adipose-derived stem cell therapies for autoimmune diseases, Crohn's disease, and degenerative conditions.
Hengrui Medicine
Oncology & Metabolic · Phase 3 · Shanghai, China · Founded 1970
Leading Chinese pharmaceutical developing novel oncology and metabolic disease drugs with global clinical development.
WuXi AppTec
Drug Discovery Platform · Commercial · Shanghai, China · Founded 2000
Global platform enabling drug discovery and development with services spanning small molecules to cell and gene therapies.
Zai Lab
Innovative Medicines · Commercial · Shanghai, China · Founded 2014
China-focused biopharma developing and commercializing innovative medicines for oncology and autoimmune diseases.
CARsgen Therapeutics
CAR-T Therapy · Phase 2 · Shanghai, China · Founded 2014
Developing next-generation CAR-T cell therapies for solid tumors and hematologic cancers with novel target antigens.
Fosun Pharma
mRNA & Cell Therapies · Commercial · Shanghai, China · Founded 1994
Major Chinese pharma with investments in mRNA vaccines, CAR-T therapies, and regenerative medicine technologies.
EdiGene
CRISPR Gene Editing · Phase 1 · Beijing, China · Founded 2015
Developing CRISPR-based gene editing therapies for hematological diseases and cancers with clinical programs in beta-thalassemia.
Biocon
Biosimilars & Biologics · Commercial · Bangalore, India · Founded 1978
India's largest biologics company developing biosimilars and novel biologics for diabetes, oncology, and autoimmune diseases.
Dr. Reddy's Laboratories
Generics & Biologics · Commercial · Hyderabad, India · Founded 1984
Major Indian pharmaceutical with growing biologics pipeline including biosimilars for age-related conditions.
Serum Institute of India
Vaccines & Biologics · Commercial · Pune, India · Founded 1966
World's largest vaccine manufacturer by doses, expanding into biologics and gene therapies for global health.
Strand Life Sciences
Genomics & Precision Medicine · Commercial · Bangalore, India · Founded 2000
Leading Indian genomics company providing precision medicine diagnostics and AI-powered drug discovery platforms.
Tessa Therapeutics
Cell Therapy · Phase 2 · Singapore · Founded 2013
Singapore-based biotech developing virus-specific T-cell therapies for solid tumors and blood cancers.
MiRXES
RNA Diagnostics · Commercial · Singapore · Founded 2014
Developing microRNA-based liquid biopsy diagnostics for early cancer detection and disease monitoring.
Esco Aster
Cell Therapy CDMO · Commercial · Singapore · Founded 2017
Singapore-based contract development and manufacturing organization specializing in cell and gene therapy production.
Compugen
Computational Drug Discovery · Phase 1 · Tel Aviv, Israel · Founded 1993
Using computational biology platforms to discover novel drug targets and develop immunotherapies for cancer.
CollPlant
Recombinant Collagen · Phase 1 · Rehovot, Israel · Founded 2004
Developing plant-derived recombinant human collagen for regenerative medicine, 3D bioprinting, and aesthetic applications.
BiomX
Phage Therapy · Phase 2 · Ness Ziona, Israel · Founded 2015
Developing microbiome-based therapeutics using designed phage cocktails for inflammatory bowel disease and dermatology.
Bonus BioGroup
Bone Regeneration · Phase 2 · Haifa, Israel · Founded 2008
Developing autologous bone tissue for regenerative medicine using patient's own cells for orthopedic applications.
Opthea
Ophthalmology · Phase 3 · Melbourne, Australia · Founded 2007
Developing OPT-302 for wet AMD and diabetic macular edema, targeting VEGF-C/D pathway as add-on therapy.
Chimeric Therapeutics
CAR-T Therapy · Phase 1 · Melbourne, Australia · Founded 2019
Australian cell therapy company developing CAR-T treatments for solid tumors including glioblastoma and ovarian cancer.
Pacific Edge
Cancer Diagnostics · Commercial · Dunedin, New Zealand · Founded 2001
New Zealand company commercializing Cxbladder, a non-invasive urine test for bladder cancer detection and monitoring.
Casma Therapeutics
Autophagy · Preclinical · Cambridge, USA · Founded 2018
Developing therapies that harness autophagy to treat neurodegenerative and age-related diseases by clearing toxic aggregates.
Frontier Medicines
Covalent Drug Discovery · Preclinical · San Francisco, USA · Founded 2017
Developing covalent small molecule drugs against previously undruggable targets using chemoproteomics platform.
Korro Bio
RNA Editing · Phase 1 · Cambridge, USA · Founded 2018
Developing ADAR-mediated RNA editing therapeutics for genetic diseases without permanently altering the genome.
Prime Medicine
Prime Editing · Preclinical · Cambridge, USA · Founded 2019
Developing prime editing gene therapy platform for precise correction of genetic mutations without double-strand breaks.
Verve Therapeutics
Cardiovascular Gene Editing · Phase 1 · Cambridge, USA · Founded 2018
Developing single-course gene editing treatments for cardiovascular disease targeting PCSK9 and other lipid genes.
Lyell Immunopharma
T-Cell Reprogramming · Phase 1 · South San Francisco, USA · Founded 2018
Developing next-generation cell therapies using T-cell reprogramming to overcome exhaustion and enhance anti-tumor activity.
Nkarta
NK Cell Therapy · Phase 1 · South San Francisco, USA · Founded 2015
Developing engineered natural killer cell therapies for cancer with enhanced persistence and tumor targeting.
Sana Biotechnology
Engineered Cells · Phase 1 · Seattle, USA · Founded 2018
Developing cell engineering platform to repair and control genes, replace missing cells, and address aging-related diseases.
Achilles Therapeutics
Neoantigen Therapy · Phase 1 · London, UK · Founded 2016
Developing personalized T-cell therapies targeting clonal neoantigens unique to each patient's tumor.
Autolus Therapeutics
CAR-T Therapy · Phase 2 · London, UK · Founded 2014
Developing next-generation programmed T-cell therapies with improved targeting and reduced toxicity for blood cancers.
Gyroscope Therapeutics
Retinal Gene Therapy · Phase 2 · London, UK · Founded 2016
Novartis-acquired company developing gene therapies for geographic atrophy secondary to dry age-related macular degeneration.
Freeline Therapeutics
AAV Gene Therapy · Phase 1 · Stevenage, UK · Founded 2015
Developing AAV-based gene therapies for hemophilia and other chronic diseases using liver-targeted delivery.
Artios Pharma
DNA Repair Oncology · Phase 1 · Cambridge, UK · Founded 2016
Developing precision medicines targeting DNA damage response pathways for synthetic lethal cancer therapy.
Fate Therapeutics
iPSC Cell Therapy · Phase 1 · San Diego, USA · Founded 2007
Developing off-the-shelf iPSC-derived NK and T cell therapies for cancer immunotherapy with potential applications in aging and regeneration.
Century Therapeutics
iPSC Immuno-Oncology · Phase 1 · Philadelphia, USA · Founded 2018
Developing allogeneic iPSC-derived immune cell therapies engineered for enhanced persistence and tumor targeting.
Garuda Therapeutics
iPSC Blood Cells · Preclinical · Cambridge, USA · Founded 2020
Engineering iPSC-derived hematopoietic stem cells for treating blood disorders and enabling regenerative medicine applications.
Cynata Therapeutics
iPSC Mesenchymal Cells · Phase 2 · Melbourne, Australia · Founded 2011
Developing Cymerus iPSC-derived mesenchymal stem cells (MSCs) for inflammatory and degenerative conditions.
Healios
iPSC Regenerative Medicine · Phase 2 · Tokyo, Japan · Founded 2011
Japanese pioneer in iPSC-derived regenerative therapies for stroke, acute respiratory distress, and liver disease.
Cyclerion Therapeutics
Mitochondrial Function · Phase 2 · Cambridge, USA · Founded 2018
Developing sGC stimulators that enhance mitochondrial function and cellular energy production for CNS and metabolic diseases.
Khondrion
Mitochondrial Disease · Phase 2 · Nijmegen, Netherlands · Founded 2010
Developing sonlicromanol (KH176) for primary mitochondrial diseases with potential applications in age-related mitochondrial dysfunction.
Minovia Therapeutics
Mitochondrial Augmentation · Phase 1 · Tel Aviv, Israel · Founded 2014
Pioneering mitochondrial augmentation therapy (MAT) by transplanting healthy mitochondria into patient cells to restore function.
Reneo Pharmaceuticals
Mitochondrial Disorders · Phase 2 · Irvine, USA · Founded 2016
Developing PPAR delta agonists to enhance mitochondrial function and fatty acid oxidation in rare metabolic diseases.
Samsara Therapeutics
Autophagy Enhancement · Preclinical · Oxford, UK · Founded 2018
Developing small molecules that selectively enhance autophagy to clear toxic protein aggregates in neurodegenerative diseases.
Casma Therapeutics
Targeted Autophagy · Preclinical · Cambridge, USA · Founded 2018
Engineering targeted protein degradation through selective autophagy (autophagy-targeting chimeras or AUTACs) for previously undruggable targets.
Caraway Therapeutics
Lysosomal Biology · Preclinical · Cambridge, USA · Founded 2019
Targeting lysosomal and autophagy pathways to develop therapies for neurodegenerative diseases including Parkinson's and GBA-related conditions.
Alkeus Pharmaceuticals
Autophagy Modulation · Phase 3 · Boston, USA · Founded 2013
Developing deuterated vitamin A derivatives that modulate autophagy and lipofuscin accumulation for Stargardt disease and dry AMD.
Xaira Therapeutics
AI Drug Discovery · Research · San Francisco, USA · Founded 2024
Launched April 2024 with $1B+ funding led by ARCH Venture. Using AI for protein and antibody design with RFdiffusion and RFantibody models.
Junevity
siRNA Cell Reset · Research · San Francisco, USA · Founded 2023
Emerged Feb 2025 with $10M seed. Developing siRNA therapeutics targeting transcription factors to reset cellular dysfunction and combat aging.
Celljevity
Epigenetic Reprogramming · Phase 2 · International · Founded 2018
Treated 1,000+ patients over 7 years with Prometheus Protocol epigenetic therapy. Claims Phase 3-level clinical evidence with zero serious adverse events.
Amplifier Therapeutics
AMPK Activation · Phase 2 · New York, USA · Founded 2020
Cambrian subsidiary with ATX-304 AMPK activator in Phase 1b/2a for cardiometabolic diseases and obesity. Targets declining AMPK activity with age.
Klotho Neurosciences
Klotho Gene Therapy · Preclinical · San Diego, USA · Founded 2022
Signed LOI to acquire Turn Bio's ERA platform in 2025. Developing Klotho-based therapeutics for neurological aging and cognitive decline.
Isterian
Fibrosis Therapeutics · Phase 1 · Cambridge, USA · Founded 2019
Cambrian subsidiary developing IST-01, a selective TG2 inhibitor for idiopathic pulmonary fibrosis and age-related tissue stiffening.
Senolytic Therapeutics
Next-Gen Senolytics · Preclinical · Barcelona, Spain · Founded 2019
Spanish biotech advancing novel senolytic compounds following Unity Biotechnology's closure. Lead candidates targeting BCL-2 family in preclinical.
About LongeviTech
LongeviTech bridges the gap between longevity research and public understanding. The platform curates and contextualizes the science of healthspan optimization for researchers, investors, clinicians, and the scientifically curious.
The database covers therapeutic modalities, company pipelines, clinical development stages, peer-reviewed mechanisms, and emerging biotechnology approaches in rejuvenation science.
How It Works
LongeviTech organizes longevity science by technology area, company, development stage, and modality. Technologies are grounded in peer-reviewed evidence and companies are categorized by focus, stage, funding, location, official website, and modality.
Longevity Glossary
A plain-language reference for the science behind healthspan extension — covering senolytics, autophagy, epigenetic clocks, NAD+, mTOR, telomeres, Yamanaka factors, rapamycin, biological age, and dozens of other core terms used across longevity research and clinical development.